000			02082cam a22002414a 4500
020			_a9780199635337
020			_a0199635331
082	0	0	_a574.87328 _bNUC
245	0	0	_aNucleic Acids in Chemistry and Biology
250			_a2nd edition.
260			_aOxford, England ; _aNew York : _bIRL Press at Oxford University Press, _c1997.
300			_axv, 528 p. : _bill. (some col.) ;
500			_aOriginally published: New York : Oxford University Press, 1996
500			_aIncludes index and Glossary
505			_aIntroduction and overview -- DNA and RNA structure -- Chemical synthesis -- Biosynthesis of nucleotides -- DNA sequence information, replication, and rearrangement -- RNA sequence information and transmission -- Covalent interactions of nucleic acids with small molecules -- Reversible interactions of nucleic acids with small molecules -- Interaction of proteins with nucleic acids -- Techniques applied to nucleic acids -- Glossary -- Index.
520			_aSince the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Nowhere is this more apparent than in the increasing efforts to determine the DNA sequence of the human genome and the development of new diagnostics of genetic disease. Recent sophistication of nucleic acids synthesis has been key to the establishment of the biotechnology industry and our improving knowledge of nucleic acid structures and interactions is noticeably influencing the design of novel drugs.This second and completely revised edition draws on the expertise of the same international group of authors to set the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.
650		0	_aNucleic acids.
700	1		_aBlackburn, G. Michael.
700	1		_aGait, Michael G.
856	4	2	_uhttp://www.loc.gov/catdir/enhancements/fy0636/94046592-d.html
856	4	1	_uhttp://www.loc.gov/catdir/enhancements/fy0639/94046592-t.html
942			_cREF
999			_c35938 _d35938